MELANOGENESIS AND CUTANEOUS DYSCHROMIA
The color of the skin is the result of the presence of various pigments. The hemoglobin contained in the red blood cells, the carotene mainly contained in the adipocytes.

The pigment that affects most of all the color of the skin is the melanin that is produced by specialized cells located in the epidermis and called melanocytes. Melanin regulates the color of the skin through a complex mechanism.

The cutaneous dyschromia are changes in skin color due to excess of melanin or, in some cases, the deposition of pigments of other nature on the epidermis. This alteration can be localized in a specific area of the body or widespread.

The discolorations or spots of the skin are not all the same, each of them has different origins and depths.

MAX WHITE
Max White is the most effective and innovative intensive treatment for hyperpigmentation, melasma, sun damage, age spots, discolorations, dark circles. It helps to reduce, reduce and prevent skin spots on the face, body and hands.

The formula of Max White is rich in active ingredients, present at high concentrations and with strong depigmenting properties, able to contrast the phenomena of both biological and chemical-physical nature that are at the base of the manifestation of these skin imperfections.

How to use MAX WHITE?
Apply the product twice a day directly on the area. The product is effective already from the first applications.

What are the key ingredients of MAX WHITE?
Glabridin
: It is an isoflavonoid extracted and isolated from the root of Glycyrrhiza glabra L. Studies in vitro and in vivo have shown that this phytoestrogen possesses numerous properties: antioxidant, anti-inflammatory, neuroprotective, antiteratogenous, antibacterial and also depigmenting when applied to the skin.

The depigmenting activity of Glabridin is due to a multifunctional action on the causes that lead to the manifestation of cutaneous dyschromia.

Vitamin C: Ascorbic Acid, almost ubiquitous molecule in nature, present mainly in citrus and green leafy vegetables, reduces the production of melanin because it is able to reduce o-DOPAchinon to the previous compound, DOPA, interrupting the oxidation process leading to the formation of melanin.

In the formula of Max White a more stable form of Vitamin C, Ascorbyl Glucoside has been added. The latter in fact turns out to be more stable to oxidation, thus increasing the performance of the product.

Arbutin: A natural glucoside of Hydroquinone, chemically known as Hydroquinone-β-D-Glucopiranoside, the mechanism of action, however, seems different, as studies on cultures of human melanocytes have suggested that it does not act on synthesis or on expression of the enzyme. Clinical studies have verified that its applications do not give the appearance of side effects, unlike the Hydroquinones.

Kojic Acid: inhibits the enzyme tyrosinase, chelating copper in the active site. Clinical studies have shown that the Kojic acid and its esters have depigmenting properties and are considered safe and non-toxic. The inhibitory effect on melanin formation is due both to the inhibiting activity of the transcription factor associated with microphthalmia (MITF), and to the inhibition of the activity of the alpha-melanocyte stimulating hormone (alpha-MSH)

Azelaic acid: The bleaching properties of azelaic acid are due to the competitive tyrosinase inhibitor action.

Niacinamide: It’s the biologically active amide of vitamin B3. Studies have shown that Niacinamide is able to inhibit the transfer of melanosomes to keratinocytes. Clinical tests have shown that the association of Niacinamide with a suitable sunscreen is able to give a greater brightness compared to the sole use of the sunscreen.

Vitamin A: Retinoic Acid also acts as a depigmenting agent and can produce a lightening effect when applied topically. The mechanism of action, although not fully clarified, is connected on one hand to the increased cell turnover of keratinocytes, thus facilitating the loss of pigment from the epidermis, on the other to an indirect strengthening of the cytotoxic effect on melanocytes of some skin depigmentants, through the inhibition of detoxification pathways (with relative increase of toxic species such as quinones).

 Pueraria (Kudzu): The root and the flower, used in traditional medicine, have various medicinal properties. Numerous studies have shown the activity of extracts of this plant towards melanogenesis. The activity of suppression of melanogenesis has been confirmed visually by the coloration of Fontana-Masson

Brassica Napus Seed Extract: Rich in antioxidants. In vitro and in vivo studies have shown that this functional ingredient is able to act against the signs of aging, reducing skin discolouring and uniforming skin color.

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