Chelaskin helps to remove post-laser redness, skin-roller, mesotherapy, filler, sclerotherapy, dermabrasion, rhinoplasty etc. Thanks to the chelating action of iron and zinc, it reduces dark circles and hyperpigmentation caused by bruising, hemosiderin dyschromia and hematomas. The free radical scavenging activity given by the presence in the formula of the arbutin, that guarantees protection from oxidative phenomena that can trigger following the treatments of aesthetic medicine. It also performs an effective purifying action, removing the dermal deposits of heavy metals that promote aging.

The new Chelaskin formula is even richer in active ingredients, present at high concentrations and with strong soothing, chelating and antiaging properties, able to counteract the phenomena of both biological and chemical-physical nature that underlie the manifestation of these imperfections skin.3

Indications
Aesthetic Medicine: bruises after filler, mesotherapy, needling, laser, RF, discoloration of sclerosing.
Aesthetic surgery: rhinoplasty, liposuction, blepharoplasty, lifting.
Home indications: dark circle, vascular sign (couperose, teleangectasie, rosacea), dark spot.

How to use
To apply on the skin and massage gently.

Dose
Each dose is of 0,15mL. The quantity to use it depends by the dimension of the area to treat. Apply Chelaskin trough a gentle massage.

Frequency
For aesthetic medicine indications one application is enough immediately after the session.
For aesthetic surgery, it needs the applications at home by the patient.
For homecare indications: apply twice (morning and evening) on the area for 2/3 days.
It is suggetsed to wait for the total absorption before makeup or bandages to use.

The main ingredients

Lactoferrin
Lactoferrin is an iron binding glycoprotein that consists of a single polypeptide chain. It is the second most abundant protein in human milk. Lactoferrin is a member of the transferrin family of non-heme iron binding proteins. Members of the transferrin family are distinguished from other iron binding proteins by their unique anion requirement for binding of iron. Lactoferrin differs from serum transferrin in its higher iron binding affinity and in its unique ability to retain iron over a broad pH rang. These differences, together with the differential tissue distribution of lactoferrin relative to other transferrins, contribute to the unique functional properties of lactoferrin.

Modulation of the immune response
Lactoferrin can regulate the cutaneous immune response when applied to the skin as an O / A emulsion. Considering that a) lactoferrin is produced at high levels in human individuals with skin allergic reactions 17, b) the protein is produced locally in the epidermis of normal skin and c) lactoferrin exhibits competitive binding to putative receptors on keratinocyte cells, thereby indicating a potential to directly modulate the function of these epidermal cells.

Lactoferrin Inhibits allergen induced cutaneous immunity
Lactoferrin functions downstream of IL-1β by interacting directly with keratinocyte cells to downregulate the de novo production of TNF-α. Further, the findings demonstrate that lactoferrin can directly inhibit local inflammatory responses in vivo by a mechanism independent of its ability to bind LPS.20

Wound re-epithelialization
Lactoferrin may be useful in wound healing, acting as a growth factor for keratinocytes, and complementary stimulating their activities when the function of EGF is compromised due to a lack of reactivity of keratinocytes or deficiency of EGF receptors, as in chronic wounds.
Importantly, Lactoferrin greatly enhanced cell viability and decreased cell apoptosis. This protective effect of LF may be another potential beneficial role of LF in wound healing.

Production of extracellular matrix components
Hyaluronic acid is an important component of the extracellular matrix in the dermis and epidermis and participates in numerous processes involved in wound healing, including cell migration and proliferation and modulation of the inflammatory response.
Lactoferrin promotes fibroblast motility by stimulating HAS2 gene expression, while the HAS2 expression level is varied in the types of fibroblasts and their physiological status. Lactoferrin promotes COL1A1 mRNA transcription and collagen synthesis in a dose-dependent manner.

Treatment of hemosiderin dyscromias and iron deposits
Ochre dermatitis is a secondary pigmentary disorder of venous stasis in which the increase in intravascular pressure and endothelial alterations cause extravasations of erythrocytes, hemosiderin-laden macrophages, and melanin deposits.
The main finding was that topical application of Lactoferrin allowed a fast and progressive reduction in the dimensions of the area of the ulcer in 9 of 9 patients and complete closure in 7 of 9 cases. The 90 days of evolution evidenced an important improvement in the injuries, with a reduction in the intensity of the brown color of the spot (9 of 9) and time to complete scarring ranging from 15 to 180 days (7 of 9).

Arbutin
Arbutin is abundant in the leaves of several plant species such as wheat, pear, and bearberry plants. Arbutin shows excellent safety and causes no adverse health effects such as toxicity and irritation. In erythrocytes, arbutin shows long-lasting radical scavenging properties and also protects a membrane lipid from oxidative stress in human skin fibroblasts. Recently, arbutin was effective in post-inflammatory hyperpigmentation (PIH), which is a reactive hypermelanosis and sequela of various inflammatory skin conditions, suggesting that arbutin can regulate not only radical-mediated stress, but also the inflammatory response.

Aloe Vera
A. vera has been proven to increase the rate of wound reduction, epithelialization and maturation. A. vera enhances the rate and quality of the inflammatory phase of wound healing. Increase in the number of blood vessels in the treated lesions could indicate the angiogenic activity of A. vera at earlier stages of wound healing which established a better perfusion and appropriate circulation in the injured area. The extracellular matrix that is produced by fibroblasts is made up of collagen, glycosaminoglycans, and elastin

Licorice Extract
Licorice (Glycyrrhiza glabra) is a traditional medicinal, sweet and soothing herb growing in several regions of the world. It is known that licorice has anti-inflammatory, anti-bacterial, antioxidative, anti-viral and expectorant properties. Licorice extract can be as effective as corticosteroids in the treatment of dermatitis, eczema and psoriasis. The inhibition of the inflammatory cascade may allow the repair of tissue damages and the prevention of carcinogenesis. The topical use of anti-inflammatory and antioxidant products can substantially ameliorate the impaired conditions, by restoring the physiological balance and skin functionality.

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